Practical oxygen therapy for newborn piglets

Oxygen dependency of cerebral oxidative phosphorylation in newborn piglets.

Changes in hemoglobin oxygenation and oxidation state of the CuA centre of cytochrome oxidase were measured with full spectral near infrared spectroscopy simultaneously with phosphorus metabolites using nuclear magnetic resonance 31P spectroscopy at high time resolution (10 seconds) during transient anoxia (FiO2 = 0.0 for 105 seconds) in the newborn piglet brain. During the onset of anoxia, the...

Resuscitation of the newborn – with or without supplemental oxygen? An experimental study in newborn piglets

Experimental model of atelectasis in newborn piglets.

BACKGROUND There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy. METHODS Thirteen newborn piglets received artificial mucus injection via t...

Oxygen therapy in the newborn period represents a challenge

After the experiments of Scheele, Priestly and especially Lavoisier, oxygen quickly came into use in adult medicine. When oxygen was introduced in newborn medicine almost 100 years ago, no critical questions seemed to be raised. When the relation between retinal damage (retinopathy of prematurity = ROP) and high oxygen in premature infants was detected more than 50 years ago, this resulted in a...

Dopamine therapy does not affect cerebral autoregulation during hypotension in newborn piglets

BACKGROUND Hypotensive neonates who have been treated with dopamine have poorer neurodevelopmental outcome than those who have not been treated with dopamine. We speculate that dopamine stimulates adrenoceptors on cerebral arteries causing cerebral vasoconstriction. This vasoconstriction might lead to a rightward shift of the cerebral autoregulatory curve; consequently, infants treated with dop...